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Gvoke HypoPen

Be Ready With Gvoke HypoPen®

The ready-to-use rescue pen for very low blood sugar in people with diabetes ages 2 and above1

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Proven to Work

Ready to Use

Simple to Administer

Katrina Headshot
Quote symbol For me, it’s a no brainer. We have to have Gvoke HypoPen with us at all times. Quote symbol
—Katrina, mother of son with type 1 diabetes
Alison smiling
Quote symbol Gvoke was a win‐win for us, because it comes premixed, and it’s two steps. After [my husband] learned the two steps, I was confident he could administer Gvoke if I experienced another severe low. Quote symbol
—Alison, who lives with type 1 diabetes
Charlie smiling
Quote symbol There is no reason why [people] shouldn’t have a tool like Gvoke that can bring them out of a severe low. Quote symbol
—Charlie, who lives with type 1 diabetes
Paloma smiling
Quote symbol I bring Gvoke wherever I go. I go on a trip, I have it. I’m on a hike, I bring it. We can’t see into the future, but Gvoke [can prepare] us for severe lows. Quote symbol
—Paloma, who lives with type 1 diabetes
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Face Severe Low Blood Sugar With Confidence

Managing blood sugar levels is challenging no matter how dedicated you are to your treatment plan. If you are on insulin or sulfonylureas for your diabetes, you’re at increased risk for low blood sugar.3 The good news? Gvoke HypoPen is a ready-to-use rescue pen you can count on to bring very low blood sugar levels back up quickly and safely — your safety net for when it matters most.1†

Discover the Simple 2-Step Administration1

Gvoke HypoPen animation
Pull Red
Remove the red cap.
Graphic dashed line
Push Yellow
Push yellow end down on skin and hold for 5 seconds. Window will turn red.
Gvoke HypoPen can be administered into the outer upper arm, lower abdomen, or outer thigh.1  Store in original sealed pouch until time of use.

Tristan’s Gvoke HypoPen Story

Learn why Tristan, a college athlete who lives with type 1 diabetes, has Gvoke HypoPen with him at all times — and how he used it to treat severe low blood sugar.

Doctor and patient

How To Get Gvoke HypoPen

If you or your loved one doesn’t have a prescription for potentially life-saving Gvoke HypoPen, talk to your doctor today.


If you live in a state that has a glucagon standing order, you can get it at your local pharmacy.

Explore the Gvoke® Blog

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Shiloh and Noah with Gvoke Pen
November 13, 2023

Tackling Life With Type 1 Diabetes: Shiloh Scores Big on His ‘Diaversary’

†In two clinical studies in adults, blood sugar levels that were less than 50 mg/dL increased to above 70 mg/dL or increased by at least 20 mg/dL within 13.8 minutes on average.


1. Gvoke [prescribing information]. Chicago, IL: Xeris Pharmaceuticals, Inc.
2. Valentine V, Newswanger B, Prestrelski S, Andre AD, Garibaldi M. Human factors usability and validation studies of a glucagon autoinjector in a simulated severe hypoglycemia rescue situation. Diabetes Technol Ther. 2019;21(9):522-530.
3. McCall AL, Lieb DC, Gianchandani R, et al. Management of individuals with diabetes at high risk for hypoglycemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2023;108(3):529-562.

*Offer not valid for prescriptions reimbursed under Medicaid, a Medicare drug benefit plan, TRICARE, or other federal or state health programs (such as medical assistance programs).

Indication and Important Safety Information⁠—⁠Read More


GVOKE is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in adults and kids with diabetes ages 2 years and above. It is not known if GVOKE is safe and effective in children under 2 years of age.


Do not use GVOKE if:

  • you have a tumor in the gland on top of your kidneys (adrenal gland), called a pheochromocytoma.
  • you have a tumor in your pancreas called an insulinoma.
  • you are allergic to glucagon or any other inactive ingredient in GVOKE.


High blood pressure
GVOKE can cause high blood pressure in certain people with tumors in their adrenal glands.

Low blood sugar
GVOKE can cause low blood sugar in certain people with tumors in their pancreas called insulinomas by making too much insulin in their bodies.

Serious allergic reaction
Call your doctor or get medical help right away if you have a serious allergic reaction including:

  • rash
  • difficulty breathing
  • low blood pressure


The most common side effects of GVOKE in adults include:

  • nausea
  • vomiting
  • swelling at the injection site
  • headache

The most common side effects of GVOKE in children include:

  • nausea
  • low blood sugar
  • high blood sugar
  • vomiting
  • abdominal pain
  • headache
  • pain or redness at the injection site
  • itching

These are not all the possible side effects of GVOKE. For more information, ask your doctor. Call your doctor for medical advice about side effects.

You are encouraged to report side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.


Before using GVOKE, tell your doctor about all your medical conditions, including if you:

  • have adrenal gland problems
  • have a tumor in your pancreas
  • have not had food or water for a long time (prolonged fasting or starvation)
  • have low blood sugar that does not go away (chronic hypoglycemia)
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.


  • Read the detailed Instructions for Use that come with GVOKE.
  • Use GVOKE exactly how your healthcare provider tells you to use it
  • Make sure your relatives, close friends, and caregivers know where you store GVOKE and how to use it the right way before you need their help.
  • Act quickly. Having very low blood sugar for a period of time may be harmful.
  • Your healthcare provider will tell you how and when to use GVOKE.
  • After giving GVOKE, your caregiver should call for emergency medical help right away.
  • If you do not respond after 15 minutes, your caregiver may give you another dose, if available. Tell your healthcare provider each time you use GVOKE. Low blood sugar may happen again after receiving an injection of GVOKE. Your diabetes medicine may need to be changed.


  • Keep GVOKE in the foil pouch until you are ready to use it.
  • Store GVOKE at temperatures between 68°F and 77°F.
  • Do not keep it in the refrigerator or let it freeze.

Keep GVOKE and all medicines out of the reach of children.

For more information, call 1-877-937-4737 or go to

Please see the Full Prescribing Information for Gvoke