Discover an Essential Tool for Your Diabetes Toolkit

Gvoke HypoPen® is the ready-to-use rescue pen for low blood sugar emergencies that anyone can administer — including you1,2
Gvoke HypoPen
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Why Do You Need Gvoke HypoPen?

During a severe low blood sugar event, you need a safety net for when it matters most


Managing blood sugar levels is challenging, no matter how dedicated you are to your treatment plan. Low blood sugar emergencies can happen unexpectedly and they demand quick action. That’s why it’s important for you and your loved ones to be ready to confidently treat severe low blood sugar.

Gvoke HypoPen
*Store in original sealed pouch until time of use.

Meet Gvoke HypoPen

Gvoke HypoPen is the ready-to-use rescue pen anyone can administer with confidence1

  • In a study with simulated emergency conditions, 99% of people used it correctly1
  • Simple to administer at a moment’s notice, like an epinephrine autoinjector for severe allergic reactions
  • You can even self-administer it in certain situations2
  • Can be administered to the outer upper arm, lower abdomen or outer thigh3
  • Brings very low blood sugar back up quickly and safely3†

Understanding Dosages

Gvoke HypoPen comes in two premeasured dosing options
that don’t require refrigeration3

Gvoke HypoPen 1mg Box

1 mg per 0.2 mL

  • For patients aged 12 and older and children under 12 years of age who weigh ≥ 100 lbs
  • Lasts up to 30 months from date of manufacture when stored at room temperature4
Gvoke HypoPen .5mg box

0.5 mg per 0.1 mL

  • For patients between the ages of 2 and 11 who weigh less than 100 lbs
  • Lasts up to 24 months from date of manufacture when stored at room temperature4

Proven safe

In clinical trials, most side effects were mild.4*

The most common side effects in adults were3:

  • Nausea(30%)
  • Vomiting (16%)
  • Swelling at the injection site (7%)
  • Headache (5%)

The most common side effects in children were3:

  • Nausea (45%)
  • Hypoglycemia (39%)
  • Vomiting (19%)
  • Headache (7%)
  • Hyperglycemia (7%)
  • Abdominal pain (3%)
  • Injection site discomfort (3%)
  • Injection site reaction (3%)
  • Urticaria (hives) (3%)

*Mild side effects are those that do not interfere with your normal day-to-day functioning.

Woman in city

Know When To Use Gvoke HypoPen

Severe low blood sugar requires immediate attention. Gvoke HypoPen should be used if you experience any of the following during a low blood sugar emergency3:

  1. Correcting with food or drink isn’t working
  2. You are unable to swallow safely
  3. You feel like passing out
  4. You pass out or have a seizure
Man talking to doctor

Where People Keep Gvoke HypoPen

Gvoke HypoPen comes in a convenient two-pack. You should have it available at all times no matter where you are. Store Gvoke HypoPen at room temperature (68°F to 77°F).3 Do not refrigerate or freeze.

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Keep Gvoke HypoPen in an easy-to-access location where you live (e.g. nightstand).

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School or work

Ensure you have Gvoke HypoPen available to treat a severe low at school or the office.

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On the go

Gvoke HypoPen is easy to travel with because it doesn’t need to be refrigerated.

†In two clinical studies in adults, blood sugar levels that were less than 50 mg/dL increased to above 70 mg/dL or increased by at least 20 mg/dL within 13.8 minutes on average.


  1. Valentine V, Newswanger B, Prestrelski S, Andre AD, Garibaldi M. Human factors usability and validation studies of a glucagon autoinjector in a simulated severe hypoglycemia rescue situation. Diabetes Technol Ther. 2019;21(9):522-530
  2. Gvoke HypoPen [instructions for use]. Chicago, IL: Xeris Pharmaceuticals, Inc; 2023.
  3. Gvoke [prescribing information]. Chicago, IL: Xeris Pharmaceuticals, Inc; 2023.
  4. Data on file. Xeris Pharmaceuticals, Inc.
Indication and Important Safety Information⁠—⁠Read More


GVOKE is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in adults and kids with diabetes ages 2 years and above. It is not known if GVOKE is safe and effective in children under 2 years of age.


Do not use GVOKE if:

  • you have a tumor in the gland on top of your kidneys (adrenal gland), called a pheochromocytoma.
  • you have a tumor in your pancreas called an insulinoma.
  • you are allergic to glucagon or any other inactive ingredient in GVOKE.


High blood pressure
GVOKE can cause high blood pressure in certain people with tumors in their adrenal glands.

Low blood sugar
GVOKE can cause low blood sugar in certain people with tumors in their pancreas called insulinomas by making too much insulin in their bodies.

Serious allergic reaction
Call your doctor or get medical help right away if you have a serious allergic reaction including:

  • rash
  • difficulty breathing
  • low blood pressure


The most common side effects of GVOKE in adults include:

  • nausea
  • vomiting
  • swelling at the injection site
  • headache

The most common side effects of GVOKE in children include:

  • nausea
  • low blood sugar
  • high blood sugar
  • vomiting
  • abdominal pain
  • headache
  • pain or redness at the injection site
  • itching

These are not all the possible side effects of GVOKE. For more information, ask your doctor. Call your doctor for medical advice about side effects.

You are encouraged to report side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.


Before using GVOKE, tell your doctor about all your medical conditions, including if you:

  • have adrenal gland problems
  • have a tumor in your pancreas
  • have not had food or water for a long time (prolonged fasting or starvation)
  • have low blood sugar that does not go away (chronic hypoglycemia)
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.


  • Read the detailed Instructions for Use that come with GVOKE.
  • Use GVOKE exactly how your healthcare provider tells you to use it
  • Make sure your relatives, close friends, and caregivers know where you store GVOKE and how to use it the right way before you need their help.
  • Act quickly. Having very low blood sugar for a period of time may be harmful.
  • Your healthcare provider will tell you how and when to use GVOKE.
  • After giving GVOKE, your caregiver should call for emergency medical help right away.
  • If you do not respond after 15 minutes, your caregiver may give you another dose, if available. Tell your healthcare provider each time you use GVOKE. Low blood sugar may happen again after receiving an injection of GVOKE. Your diabetes medicine may need to be changed.


  • Keep GVOKE in the foil pouch until you are ready to use it.
  • Store GVOKE at temperatures between 68°F and 77°F.
  • Do not keep it in the refrigerator or let it freeze.

Keep GVOKE and all medicines out of the reach of children.

For more information, call 1-877-937-4737 or go to

Please see the Full Prescribing Information for Gvoke