Do You Have the Right Tools to Treat Very Low Blood Sugar?
ADA recommends ready-to-use glucagon for those at high risk for hypoglycemia

The American Diabetes Association recently updated its guidelines for healthcare professionals. If you or your loved one takes medications that lower your blood sugar, such as insulin or insulin secretagogues (sulfonylureas, meglitinides), it’s important to be aware of the updated guidelines related to hypoglycemia and ready-to-use glucagon. Being informed about the latest guidance will help you engage with your healthcare provider to understand your risk, identify the necessary tools for your diabetes toolkit, and determine when to use them so that you can keep yourself or your loved one safe.
Why are the ADA guidelines important?
The ADA Standards of Care are guidelines for healthcare professionals made by diabetes experts. They give recommendations on how to manage diabetes, and every year, these guidelines are updated with new research and insights to help people with diabetes, their loved ones, and doctors manage diabetes in the best way possible.
2024 ADA Guidelines: What’s New?
The ADA makes it clear that individuals taking insulin or insulin secretagogues (i.e., sulfonylureas, meglitinides) are at risk for experiencing low blood sugar. While these medicines are important for managing blood sugar levels, they can sometimes make your blood sugar levels go too low. So, the ADA says1:
- You or your loved one should have a prescription for ready-to-use glucagon if taking:
- Insulin
- Sulfonylureas or meglitinides and have major risk factors such as recent blood sugar < 54 mg/dL, or low blood sugar unawareness. Discuss low blood sugar risk factors with your healthcare provider.
- Those in close contact with you or your loved one should learn where the ready-to-use glucagon is kept, how to use it, and when it is needed.
- You or your loved one should discuss low blood sugar (hypoglycemia) management during your first appointment, follow-up visits, and yearly check-ups with your doctor.
Why Ready-to-Use Glucagon Must Be in Your Diabetes Toolkit
Very low blood sugar can happen suddenly, and you need to act fast when it does. That’s where ready-to-use glucagon like Gvoke HypoPen® comes in. Gvoke HypoPen is the ready-to-use glucagon rescue pen anyone can administer2,3 with confidence.
- Simple to administer. Anyone can administer in two simple steps,2,4 including you in certain situations.
- Ready to Use. It’s premixed and ready to go at a moment’s notice.3
- Proven to work. Brings very low blood sugar back up quickly and safely.3*
Think of it as your safety net for when it matters most.
When to Use Ready-to-Use Glucagon
Because glucagon can rapidly reverse very low blood sugar, it’s viewed as one of the primary treatments for it.5
You can use ready-to-use glucagon when:
- Correcting with food or drink isn’t working.
- You are unable to swallow safely.
- You feel like passing out.
- You pass out or have a seizure.
Talk to Your Doctor
Given the ADA’s latest guideline updates, having ready-to-use glucagon is no longer just a suggestion, but an essential tool for patients on insulin or at high risk for low blood sugar. You deserve to feel equipped, supported, and empowered in your diabetes management by having a safety net for when you need it most.
Talk to your doctor today about risk factors for very low blood sugar and including Gvoke HypoPen® in your diabetes toolkit to align with the latest guidance!
*In two clinical studies in adults, blood sugar levels that were less than 50 mg/dL increased to above 70 mg/dL or increased by at least 20 mg/dL within 13.8 minutes on average.
References:
- American Diabetes Association Professional Practice Committee. 6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes—2024. Diabetes Care. 2024; 47 (Suppl 1): S111–S125. doi.org/10.2337/dc24-S006.
- Valentine V, Newswanger B, Prestrelski S, Andre AD, Garibaldi M. Human factors usability and validation studies of a glucagon autoinjector in a simulated severe hypoglycemia rescue situation. Diabetes Technol Ther. 2019;21(9):522-530.
- Gvoke [prescribing information]. Chicago, IL: Xeris Pharmaceuticals, Inc.
- Gvoke HypoPen [instructions for use]. Chicago, IL: Xeris Pharmaceuticals, Inc.
- McCall AL, Lieb DC, Gianchandani R, et al. Management of individuals with diabetes at high risk for hypoglycemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2023;108(3):529-562.doi:10.1210/clinem/dgac596.
US-GVK-24-0005v3 01/25
Indication
GVOKE (glucagon) is a prescription medicine used to treat very low blood sugar in adults and children ages 2 years and above with diabetes.
Important Safety Information
- Do not use GVOKE if you:
-
- Have a tumor in the gland on top of your kidneys, called a pheochromocytoma because of the risk of a substantial increase in blood pressure
- Have a tumor in your pancreas called an insulinoma because of the risk of low blood sugar
- Are allergic to glucagon or any inactive ingredient in GVOKE. Stop using GVOKE and seek immediate medical attention if you experience any symptoms of a serious allergic reaction such as rash, difficulty breathing, or low blood pressure
- Before using GVOKE, tell your doctor about all the medicines you take and your medical conditions, including if you have not had food or water for a long time (prolonged fasting or starvation), have low blood sugar that does not go away (chronic hypoglycemia), or have a history of a skin rash called necrolytic migratory erythema (commonly associated with glucagon-producing tumors)
- The most common side effects reported in adults are nausea, vomiting, swelling at the injection site, and headache
- The most common side effects reported in children are nausea, low blood sugar, vomiting, headache, abdominal pain, high blood sugar, pain or redness at injection site, and hives
- Inform caregivers on the Instructions for Use of GVOKE, and symptoms of severe hypoglycemia, which include unconsciousness and seizures or convulsions
- Store in original container until time of use, and at room temperature between 68°F to 77°F (20° C to 25° C)
- You are encouraged to report side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088
Please talk to your doctor and see full Prescribing Information and Patient Information Guide for GVOKE.