Get ready for school Equip your child’s school with tools for very low blood sugar.

Get tools

Learn How To Use
Gvoke HypoPen®

Treat a severe low blood sugar event with a ready-to-use glucagon rescue pen in 2 simple steps.1

See full Instructions for Use.

Discover the Simple 2-Step Administration1

Gvoke HypoPen animation
Pull Red
Remove the red cap.
Graphic dashed line
Push Yellow
Push yellow end down on skin and hold for 5 seconds. Window will turn red.
Gvoke HypoPen can be administered into the outer upper arm, lower abdomen, or outer thigh.1  Store in original sealed pouch until time of use.

Know When To Use Gvoke HypoPen

Severe low blood sugar requires immediate attention. Gvoke HypoPen should be used if you experience any of the following during a low blood sugar emergency1:


  1. Correcting with food or drink isn’t working
  2. You are unable to swallow safely
  3. You feel like passing out
  4. You pass out or have a seizure
Man talking to doctor
Kenny smiling
Quote symbol I just ripped open the pouch, took Gvoke® out, removed the cap, injected it into my belly. A couple of minutes later, I started to feel better.* Quote symbol
—Kenny, living with type 1 diabetes
*Individual results may vary
Megaphone icon

Educate Others About
Gvoke HypoPen

It’s important that the people around you know you have Gvoke HypoPen, where to find it and how to use it. That way, they’ll be ready to help you during a low blood sugar emergency.


  1. Gvoke [prescribing information]. Chicago, IL: Xeris Pharmaceuticals, Inc; 2023.
Indication and Important Safety Information⁠—⁠Read More


GVOKE is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in adults and kids with diabetes ages 2 years and above. It is not known if GVOKE is safe and effective in children under 2 years of age.


Do not use GVOKE if:

  • you have a tumor in the gland on top of your kidneys (adrenal gland), called a pheochromocytoma.
  • you have a tumor in your pancreas called an insulinoma.
  • you are allergic to glucagon or any other inactive ingredient in GVOKE.


High blood pressure
GVOKE can cause high blood pressure in certain people with tumors in their adrenal glands.

Low blood sugar
GVOKE can cause low blood sugar in certain people with tumors in their pancreas called insulinomas by making too much insulin in their bodies.

Serious allergic reaction
Call your doctor or get medical help right away if you have a serious allergic reaction including:

  • rash
  • difficulty breathing
  • low blood pressure


The most common side effects of GVOKE in adults include:

  • nausea
  • vomiting
  • swelling at the injection site
  • headache

The most common side effects of GVOKE in children include:

  • nausea
  • low blood sugar
  • high blood sugar
  • vomiting
  • abdominal pain
  • headache
  • pain or redness at the injection site
  • itching

These are not all the possible side effects of GVOKE. For more information, ask your doctor. Call your doctor for medical advice about side effects.

You are encouraged to report side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.


Before using GVOKE, tell your doctor about all your medical conditions, including if you:

  • have adrenal gland problems
  • have a tumor in your pancreas
  • have not had food or water for a long time (prolonged fasting or starvation)
  • have low blood sugar that does not go away (chronic hypoglycemia)
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.


  • Read the detailed Instructions for Use that come with GVOKE.
  • Use GVOKE exactly how your healthcare provider tells you to use it
  • Make sure your relatives, close friends, and caregivers know where you store GVOKE and how to use it the right way before you need their help.
  • Act quickly. Having very low blood sugar for a period of time may be harmful.
  • Your healthcare provider will tell you how and when to use GVOKE.
  • After giving GVOKE, your caregiver should call for emergency medical help right away.
  • If you do not respond after 15 minutes, your caregiver may give you another dose, if available. Tell your healthcare provider each time you use GVOKE. Low blood sugar may happen again after receiving an injection of GVOKE. Your diabetes medicine may need to be changed.


  • Keep GVOKE in the foil pouch until you are ready to use it.
  • Store GVOKE at temperatures between 68°F and 77°F.
  • Do not keep it in the refrigerator or let it freeze.

Keep GVOKE and all medicines out of the reach of children.

For more information, call 1-877-937-4737 or go to

Please see the Full Prescribing Information for Gvoke