Gvoke is easy to use1-3

When to use Gvoke2

Gvoke can be used to treat a very low blood sugar event when someone:

blood cell character showing when correcting with food and drink isn't working

Has repeatedly tried correcting with food or drink and it isn't working

blood cell character that is unable to swallow safely

Is unable to swallow safely

blood cell character having feelings of passing out

Feels like you/they might pass out

blood cell character experiencing loss of consciousness or a seizure

Experiences loss of consciousness or a seizure

It's important to remember that Gvoke can be used even before you or the person you're helping passes out or has a seizure. It's a good idea for you and the people in your life to know how to use it before you need it.

Bring blood sugar up with just 2 simple steps1,2

Gvoke Pre-Filled Syringe (PFS) comes in an individually packaged, sealed foil pouch. Make sure you keep Gvoke in its original sealed pouch until you are ready to use it. When it is needed, remove Gvoke from the pouch and follow these simple steps:

1. Prepare

Pull cap straight off the syringe.

hand holding Gvoke Pre-Filled Syringe hands showing the removal of the cap straight off the Gvoke Pre-Filled Syringe
2. Inject

Pinch the skin of the upper arm, lower stomach, or outer thigh and insert the needle at a 90-degree angle.

Push the plunger down as far as it will go.

image of Gvoke Pre-Filled Syringe injection
call 911 for emergency help


After using Gvoke, you should lay or be turned on your side and call for emergency help.

megaphone announcing study results

Good news! In studies, people prepared and administered a full dose of Gvoke PFS successfully 99% of the time*3

simple 2-step instructions for using Gvoke Pre-Filled Syringe

Find simple 2-step instructions for using Gvoke PFS

Gvoke PFS Guide

Usability study with simulated emergency conditions.

References: 1. Gvoke [prescribing information]. Chicago, IL: Xeris Pharmaceuticals, Inc. 2. Gvoke Pre-Filled Syringe [instructions for use]. Chicago, IL: Xeris Pharmaceuticals, Inc. 3. Newswanger B, Prestrelski S, Andre AD. Human factors studies of a prefilled syringe with stable liquid glucagon in a simulated severe hypoglycemia rescue situation. Expert Opin Drug Deliv. 2019;16(9):1015-1025.