Reliable method of delivery1-5

Gvoke is premixed and ready-to-go, so it is ready-to-use1-3


Gvoke HypoPen®

In a functional efficacy study

Gvoke HypoPen® (glucagon injection)

99%

of participants (74/75) were able to successfully administer Gvoke HypoPen2,4*

Objective:
To assess if Gvoke could be safely and effectively administered by the appropriate user groups and to assess the effectiveness of product labeling.

Untrained participants:
Given time to familiarize themselves as desired with the device, IFU and Label Guide.

Trained participants:
Introduced to the purpose, dosing and details of the device and procedure, provided time to review the IFU, Label Guide and device, and were given a verbal walk‑through of the device.

All participants returned ~1 week later.

Glucagon Emergency Kit

In a comparative usability study

Traditional glucagon kit

31%a

of participants (5/16) were able to successfully administer a traditional glucagon emergency kit4,*

Objective:
To evaluate the ease of use of Gvoke HypoPen versus the traditional glucagon kits that require mixing in a comparative usability study.

Untrained participants:
Did not receive any form of training.

Trained participants:
Received training from the moderator on how to prepare and administer a glucagon injection, an overview of the device and a verbal walk-through of the procedurer device and a verbal walk-through of the procedure.

aIn the usability study, 88% (14) successfully administered a rescue injection using the GAI versus 31% (5) using GEKs (P<0.05). Results from this study were used to inform the final Gvoke HypoPen Instructions for Use, which was evaluated in the summative human factors validation study.

*Administering glucagon in simulated emergencies.


Anyone can use Gvoke with 2 simple steps1-5


Pull red cap off of the Gvoke HypoPen®.
1

Pull red

cap off

Push yellow end into upper arm, lower stomach, or outer thigh; wait 5 seconds for the window to turn red.
2

Push yellow

end down on skin and hold 5 seconds. Window will turn red.

Administer into upper arm, stomach, or thigh.

After using Gvoke, turn person on their side if they are passed out or seizing. Call for emergency help.2,3

See how Gvoke HypoPen is administered in this 20-second video

References: 1. Gvoke [prescribing information], Chicago, IL; Xeris Pharmaceuticals, Inc. 2. Gvoke HypoPen [instructions for use], Chicago, IL: Xeris Pharmaceuticals, Inc. 3. Gvoke Pre-Filled Syringe [instructions for use], Chicago, IL: Xeris Pharmaceuticals, Inc. 4. Valentine V, Newswanger B, Prestrelski S, Andre AD, Garibaldi M. Human factors usability and validation studies of a glucagon autoinjector in a simulated severe hypoglycemia rescue situation. Diabetes Technol Ther. 2019;21(9):522-530. 5. Newswanger B, Prestreleski S, Andre AD. Human factor studies of a prefilled syringe with stable liquid glucagon in a simulated severe hypoglycemia rescue situation. Expert Opin Drug Deliv. 2019;16(9):1015-1025.

Pull cap straight off the syringe.
1

Prepare

Pull cap straight off the syringe.

Pinch the skin of the upper arm, lower stomach, or outer thigh and insert the needle at a 90-degree angle. Push the plunger down as far as it will go.
2

Inject

Pinch the skin and insert the needle at a 90‑degree angle. Push the plunger down as far as it will go.

Inject into upper arm, stomach, or thigh.

After using Gvoke, turn person on their side if they are passed out or seizing. Call for emergency help.2,3


Hear real people with diabetes talk about using Gvoke PFS.

References: 1. Gvoke [prescribing information], Chicago, IL; Xeris Pharmaceuticals, Inc. 2. Gvoke HypoPen [instructions for use], Chicago, IL: Xeris Pharmaceuticals, Inc. 3. Gvoke Pre-Filled Syringe [instructions for use], Chicago, IL: Xeris Pharmaceuticals, Inc. 4. Valentine V, Newswanger B, Prestrelski S, Andre AD, Garibaldi M. Human factors usability and validation studies of a glucagon autoinjector in a simulated severe hypoglycemia rescue situation. Diabetes Technol Ther. 2019;21(9):522-530. 5. Newswanger B, Prestreleski S, Andre AD. Human factor studies of a prefilled syringe with stable liquid glucagon in a simulated severe hypoglycemia rescue situation. Expert Opin Drug Deliv. 2019;16(9):1015-1025.